In one instance, a single patient was misclassified as having low-severity major depressive disorder at intake when he actually had high-severity major depressive disorder. There were other errors that led us to conduct an intensive review of the data. Correcting these errors affected the cell sizes reported in Figures 2 and 3 and the exact values of the tests reported and also resulted in a change in the interaction between severity and treatment condition, which is no longer a statistically significant interaction. In the process of hand-checking our data, we also found 2 patients who were credited with remissions that they did not achieve (1 in each group). Differences between the treatment conditions were largely unaffected but the median time to recovery was reduced. In addition, 282 patients recovered earlier and 16 patients recovered later than was initially recognized in our analyses. There were 5 additional patients who recovered in the combined treatment group (the correct number is 170 not 165), and 8 additional patients who recovered in the medications only group (the correct number is 148 not 140). This resulted in missing recoveries in 13 patients. The major problem with our original reported data was that the automated algorithm that we used to track patient progress sometimes failed to recognize remissions or recoveries that occurred or it recognized only later instances. Because of these errors, we have reconducted our analyses with the correct data, have corrected all findings and interpretations, and have requested that JAMA Psychiatry retract and replace the original article. Three of the findings that were previously reported as statistically significantly different are no longer significantly different: the interaction between recovery rate and severity, the number of patients who dropped out of each group, and the number of serious adverse events in each group. However, the corrections do result in changes to numerous data in the Abstract, text, Table, and Figures. These errors, once corrected, have not changed the final conclusion of this study-that cognitive therapy combined with antidepressant medication treatment enhanced rates of recovery relative to treatment with medication alone. To the Editor We write to report that we have discovered a number of pervasive errors in our published trial comparing recovery rates for major depressive disorder with cognitive therapy and medication vs medication alone (Effect of Cognitive Therapy With Antidepressant Medications vs Antidepressants Alone on the Rate of Recovery in Major Depressive Disorder: A Randomized Clinical Trial.
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